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HIV Nef inhibits T cell migration Groopman JE, et al.
Journal of Biological Chemistry
277 (48): 46079-46084 NOV 29 2002
Link The data indicate that HIV Nef altered critical downstream molecules in the CXCR4 pathway, including focal adhesion kinases. These findings suggest that HIV Nef may blunt the T cell response to chemokines. Because T lymphocyte migration is an integral component of host defense, HIV Nef may thereby contribute to the pathogenesis of AIDS.
—Posted: December 30, 2002
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