Interactions of human antibodies, epitope exposure, antibody binding and neutralization of primary isolate HIV-1 virions
Cavacini LA, et al.Conclusions: Neutralizing epitopes are obscured on intact primary isolate virions and are dynamically exposed upon ligand (CD4) interactions. Interestingly, a non-neutralizing antibody to gp41 also increased binding and neutralizing activity of some hMAb that poorly neutralized R5 virus. These data suggest that non-neutralizing epitopes may be appropriate targets for vaccine design and epitope exposure should be considered in the development of immunotherapeutic strategies for HIV.
—Posted: December 4, 2002
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