T-cell responses induced in normal volunteers immunized with a DNA-based vaccine containing HIV-1 env and rev
Weiner DB, et al.Conclusion: We observed HIV-1 DNA plasmid vaccines induce CD4 T-helper cell responses in humans. We observed a discrepancy in the CD4 versus CD8 response suggesting the importance of analyzing both compartments in clinical evaluation. Furthermore, this report demonstrates the high level of immunogenicity of rev and its importance as a component of a prophylactic vaccine for HIV-1.
—Posted: December 4, 2002
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