HIV-1 superinfection despite broad CD8+ T-cell responses containing replication of the primary virus
Marcus Altfeld et al.Here they show that sudden breakthrough of plasma viraemia occurred after prolonged immune containment in an individual infected with HIV-1 at a time when 25 distinct CD8+ T-cell epitopes in the viral proteins Gag, RT, Integrase, Env, Nef, Vpr, Vif and Rev were being targeted. Sequencing of the virus in plasma and cells showed that superinfection with a second clade-B virus was coincident with the loss of immune control. This sudden increase in viraemia was associated with a decline in half of the CD8+ T-cell responses.
420, 434 - 439 (2002)
—Posted: November 28, 2002
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