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HIV-1 superinfection despite broad CD8+ T-cell responses containing replication of the primary virus Marcus Altfeld et al.
Nature
420, 434 - 439 (2002)
Link Here they show that sudden breakthrough of plasma viraemia occurred after prolonged immune containment in an individual infected with HIV-1 at a time when 25 distinct CD8+ T-cell epitopes in the viral proteins Gag, RT, Integrase, Env, Nef, Vpr, Vif and Rev were being targeted. Sequencing of the virus in plasma and cells showed that superinfection with a second clade-B virus was coincident with the loss of immune control. This sudden increase in viraemia was associated with a decline in half of the CD8+ T-cell responses.
—Posted: November 28, 2002
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