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Immune-mediated positive selection drives human immunodeficiency virus type 1 molecular variation and predicts disease duration Howard A. Ross and Allen G. Rodrigo
Journal of Virology
November 2002, p. 11715-11720, Vol. 76, No. 22
Link They show here that the broad genetic diversity of HIV-1 in an infected individual is a consequence of site-specific positive selection for diversity, a likely consequence of immune recognition. In particular, the extent of positive selection appears to be a good predictor of disease duration.
—Posted: October 31, 2002
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