In vivo inactivation of Nef ITAM motif of chimeric simian/human immunodeficiency virus SHIVsbg-YE correlates with absence of increased virulence in chinese rhesus macaques
Aubertin AM, et al.Here, they demonstrate that the nef ITAM domain is inactivated in animals developing an acute antiviral immune response and may be detrimental to viral replication, perhaps by interfering with other well-conserved functions of SIV Nef protein.
313(1), 15 August 2003, 322-334
—Posted: December 11, 2003
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