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In vivo inactivation of Nef ITAM motif of chimeric simian/human immunodeficiency virus SHIVsbg-YE correlates with absence of increased virulence in chinese rhesus macaques Aubertin AM, et al.
313(1), 15 August 2003, 322-334
Link Here, they demonstrate that the nef ITAM domain is inactivated in animals developing an acute antiviral immune response and may be detrimental to viral replication, perhaps by interfering with other well-conserved functions of SIV Nef protein.
—Posted: December 11, 2003
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