HIV-1 in genital tract and plasma of women: Compartmentalization of viral sequences, coreceptor usage, and glycosylation
Weiser B, et al.Here, they compared HIV-1 gp120 env sequences from the genital tract and plasma of 12 women. The data demonstrate that the genital tract and plasma can harbor populations of replicating HIV-1 with different phenotypes. The association of higher CD4+ cell counts with compartmentalization of viral genomes and density of gp120 glycosylations suggests that the immune response influences the development of viral genotypes in each compartment.
Proc. Natl. Acad. Sci. USA
October 28, 2003, 100(22), 12972-12977
—Posted: November 18, 2003
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