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HIV-1 in genital tract and plasma of women: Compartmentalization of viral sequences, coreceptor usage, and glycosylation Weiser B, et al.
Proc. Natl. Acad. Sci. USA
October 28, 2003, 100(22), 12972-12977
Link Here, they compared HIV-1 gp120 env sequences from the genital tract and plasma of 12 women. The data demonstrate that the genital tract and plasma can harbor populations of replicating HIV-1 with different phenotypes. The association of higher CD4+ cell counts with compartmentalization of viral genomes and density of gp120 glycosylations suggests that the immune response influences the development of viral genotypes in each compartment.
—Posted: November 18, 2003
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