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Attenuated nef DNA vaccine construct induces cellular immune response: role in HIV-1 multiprotein vaccine Ayyavoo V, et al. Immunology Letters 2003 Oct 31;89(2-3):207-14 Link Here, they compared the immunogenicity of non-functional nef vaccine constructs to wild type functional nef as potential immunogen in mice. The results indicate that functionally attenuated Nef antigen might be a better candidate for future multiprotein HIV-1 vaccine.
—Posted: November 10, 2003
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