Effector HIV-specific cytotoxic T-lymphocyte activity in long-term nonprogressors: Associations with viral replication and progression
Keoshkerian E, et al.Ex vivo effector cytotoxic T-lymphocyte (CTL) activity was assessed in 27 members of the Australian Long-Term Nonprogressor cohort and correlated with genetic, virological, and immunological markers. There were no significant associations between CTL response and chemokine receptor genotype. The findings demonstrate the importance of HIV replication in generating an effector CTL response and show that effector CTL activity may be an early predictor of progression in people with long-term asymptomatic HIV infection.
Journal of Medical Virology
71 (4): 483-491 DEC 2003
—Posted: November 7, 2003
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