Functional evolution of the HIV-1 envelope glycoprotein 120 association site of glycoprotein 41
Poumbourios P, et al.In this study, the function of conserved gp120 contact residues, Leu593, Trp596, Gly597, Lys601, and Trp610 within the disulfide-bonded region of gp41, was examined in envelope glycoproteins derived from diverse HIV-1 isolates. They found that the gp120-gp41 association function of the disulfide-bonded region is conserved. However, the contribution of individual residues to gp41 folding and/or stability, gp120-gp41 association, membrane fusion function, and viral entry varied from isolate to isolate.
Journal of Biological Chemistry
278(43), 42149-42160, October 24, 2003
—Posted: November 6, 2003
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