Atomic force microscopy investigation of human immunodeficiency virus (HIV) and HIV-infected lymphocytes
McPherson A, et al.Isolated human immunodeficiency virus (HIV) and HIV-infected human lymphocytes in culture have been imaged for the first time by atomic force microscopy (AFM). Although >95% of HIV-infected H9 lymphocytic cells were producing HIV antigens by immunofluorescent assay, most lymphocytes displayed few or no virus on their surfaces, while others were almost covered by a hundred or more viruses, suggesting a dependence on cell cycle or physiology. HIV-infected cells treated with a viral protease inhibitor and their progeny viruses were also imaged by AFM and were indistinguishable from untreated virions.
Journal of Virology
November 2003, 77(22), 11896-11909
—Posted: November 3, 2003
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