Sensitivity analysis for the assessment of causal vaccine effects on viral load in HIV vaccine trials
Gilbert PB, et al.A standard test that compares the distribution of viral load between the infected subgroups of vaccine and placebo recipients does not assess a causal effect of vaccine, because the comparison groups are selected after randomization. To address this problem, the authors formulate clinically relevant causal estimands using the principal stratification framework developed by Frangakis and Rubin (2002, Biometrics 58, 21-29), and propose a class of logistic selection bias models whose members identify the estimands.
59 (3): 531-541 SEP 2003
—Posted: September 29, 2003
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