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B7-H1 is up-regulated in HIV infection and is a novel surrogate marker of disease progression Clerici M, et al.
Blood
101 (7): 2514-2520 APR 1 2003
Link The ligation of programmed death-ligand 1 (B7-H1) to T cells results in the preferential production of interleukin 10 (IL-10). Here they investigated if B7-H1 would be upregulated in HIV infection, a disease characterized by increased IL-10 production, by measuring, B7-H1, B7-1 (CD80), and B7-2 (CD86) expression and mRNA in 36 HIV-infected patients and in 22 healthy controls (HCs). Aberrant antigen presentation by antigen-presenting cells (APCs) that exhibit increased B7-H1 expression and IL-10 production in HIV infection could be responsible for T-lymphocyte unresponsiveness and loss of protective immunity. B7-H1 is a surrogate marker potentially involved in AIDS disease progression. (virology)
—Posted: April 18, 2003
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