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Inhibition of human immunodeficiency virus type 1 env-mediated fusion by DC-SIGN Schwartz O, et al.
Journal of Virology
May 2003, 77(9), 5313
Link Results indicate that DC-SIGN exerts subtle and complex effects during early steps of HIV type 1 replication. DC-SIGN facilitates capture and accumulation of viral particles in a vesicular compartment and inhibits viral fusion. Competition between CD4 and DC-SIGN for Env binding likely affects virus access to the cytosol and syncytium formation. (virology)
—Posted: April 17, 2003
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