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Natural variation of the nef gene in human immunodeficiency virus type 2 infections in Portugal Berry N, et al.
Journal of General Virology
84 (2003), 1287-1299
Link The central P104xxPLR motif exhibited wide interpatient variation, ranging from an HIV-1-like tetra-proline structure (PxxP)3 to a disrupted minimal core motif (P104xxQLR). The P107-->Q substitution was associated with an asymptomatic phenotype (Fisher's exact test, P=0·026) and low virus loads. These data indicate that discrete differences in the nef gene sequence rather than gross structural changes are more likely to play a role in HIV-2 pathogenesis mediated via specific functional interactions. (virology)
—Posted: April 17, 2003
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