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Potential role for CD63 in CCR5-mediated human immunodeficiency virus type 1 infection of macrophages O'Brien WA, et al.
Journal of Virology
March 2003, p. 3624-3633, 77(6)
Link Pretreatment of primary macrophages with anti-CD63 MAb, but not MAbs to other macrophage cell surface tetraspanins (CD9, CD81, and CD82), was shown to inhibit infection by several R5 and dualtropic strains, but not by X4 isolates. The block to productive infection was postfusion, as assessed by macrophage cell-cell fusion assays, but was prior to reverse transcription, as determined by quantitative PCR assay for new viral DNA formation. (virology)
—Posted: March 6, 2003
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