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Interferon-a restores HIV-induced alteration of natural killer cell perforin expression in vivo Corbeau P, et al.
AIDS
2003; 17(4):495-504
Link The percentage and the activity of natural killer (NK) cells are known to be decreased in HIV-infected patients. The results suggest that HIV-induced NK deficiency could be partly mediated by a defect in perforin and granzyme A expression, and that PEG-IFNalpha could be used in infected subjects to directly improve their natural immunity in addition to eventually reducing their viraemia. (virology)
—Posted: February 25, 2003
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