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IL-15 enhances survival and function of HIV-specific CD8(+) T cells Katsikis PD, et al.
Blood
101 (3): 1024-1029 FEB 1 2003
Link HIV-specific CD8(+) T cells are prone to undergo apoptosis, and this may affect their ability to control HIV infection. They show here that interleukin 15 (IL-15) potently inhibits spontaneous and CD95/Fas-induced apoptosis of HIV-specific CD8(+) T cells, enhances the survival of HIV-specific CD8(+) T cells in long-term cultures, and directly enhances activation, interferon gamma (IFNgamma) production, and direct ex vivo cytotoxicity of HIV-specific CD8(+) T cells. (virology)
—Posted: February 21, 2003
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