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Immunization with low doses of HIV-1 tat DNA delivered by novel cationic block copolymers induces CTL responses against Tat Caputo A, et al.
Vaccine
2003 Mar 7;21(11-12):1103-1111
Link Here, they show that a novel class of cationic block copolymers protect the DNA from DNAse I digestion, and improve DNA delivery to antigen-presenting cells (APCs) after intramuscular (i.m.) vaccination. The results indicate that vaccination with a very low dose (1 mg) of pCV-tat delivered by the cationic block copolymer K2 is safe and, as compared to naked DNA (up to 30 mg), greatly increases the CTL response against Tat, which was detected in all animals in the absence or in the presence of re-stimulation. (vaccines)
—Posted: February 10, 2003
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