From Science: Induction of APOBEC3G ubiquitination and degradation by an HIV-1 Vif-Cul5-SCF complex HIV-1 Vif is essential for viral evasion of host antiviral factor APOBEC3G (CEM15). In this study, they identified cellular proteins that interact with HIV-1 Vif and are critical to Vif ís ability to suppress the antiviral activity of APOBEC3G. Since suppression of host antiviral activity by Vif is essential for HIV-1 infection, strategies that interfere with the interaction of Vif with host cell proteins and/or degradation of APOBEC3G may lead to the design of novel anti-HIV drugs.
Hot News: Human immunodeficiency virus type 1 escape from RNA interference Researchers have found that the antiviral activity of tat short hairpin RNA (shRNA) was abolished due to the emergence of viral quasispecies harboring a point mutation in the shRNA target region. If this turns out to be a generalized occurrence, it could severely limit the use of RNA interference as a therapeutic tool. Journal of Virology 77(21), 11531, November 2003.