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February 4, 2012
 
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Vol. 3, No. 15, 1 August 2003
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AIDScience Perspectives:
CD8+ memory T cells require CD4+ T cell help: Implication for therapeutic and preventive HIV vaccines
Some preventive and therapeutic HIV vaccines in development have focused on stimulating CD8+ T cell immunity. Recent small animal studies, however, suggest that CD4+ T cells may play a critical role in nurturing CD8+ T cells that are more effective in controlling viral replication.

— By Ronald B. Moss and Peter L. Salk 
[About AIDScience articles] [See recent AIDScience articles]
 
Hot News:
Internet facilitates risky sex
A growing number of gay and bisexual men meet their sex partners online, with many subsequently engaging in risky sexual behavior, according to two new studies.
 
New research highlights HIV prevention needs
Research presented at the 2003 National HIV Prevention Conference provides new insight into prevention challenges faced by populations that are especially vulnerable to HIV infection, including youth and people of color.
 
U.S. CDC: HIV rising among gay, bisexual men
The number of newly diagnosed cases of HIV among gay and bisexual men rose in 2002 for the third straight year — a disturbing turnaround from the 1990s that health officials say reflects growing complacency about the dangers of AIDS.
 
U.S. CDC announces new system for tracking HIV infections nationwide
A new, national system for measuring the rate of HIV infections in the United States is expected to provide the clearest picture yet of the magnitude of the domestic HIV epidemic. The U.S. CDC introduced its new HIV tracking system at the 2003 National HIV Prevention Conference.
 
Latest News Headlines
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More testing for HIV urged at bathhouses
Savient Pharmaceuticals initiates phase II clinical study of Prosaptide
Gilead says profit increased fivefold
South Africa still doubts value of AIDS drug
The culture of disease (opinion)
India urges parliamentarians to join fight against AIDS in Asia
Australian company to trial anti-HIV gel on humans
Relapsing on AIDS (editorial)
Gilead's research goes to front lines
AIDS activists jeer senior Bush health official
Bush defends AIDS funding, renews pledge
South Africa may ban key mother-child AIDS drug
E.U. agency warns on GSK-Gilead HIV drug cocktail
WHO confident of meeting ambitious AIDS drugs goal
HIV patients at risk of cancer
India needs more cash and frank talking to beat AIDS epidemic
WHO looks to ease access to AIDS drugs
OraQuick rapid HIV-1 antibody test approved in Mexico
Activists blast CDC HIV prevention effort
New research highlights HIV prevention needs
Internet facilitates risky sex
From Eli Lilly to front line
U.S. sees HIV cases rise among gay, bisexual men
Gaps in AIDS counseling, testing raise fears
U.S. CDC: HIV rising among gay, bisexual men
Curbing perinatal HIV transmission in U.S. still poses challenges
Agency seeks a virus-killer for women
Rise of internet fuels fears of AIDS resurgence
New chemotherapy strategy cures lymphomas in AIDS patients
Ignorance hinders the AIDS fight, researchers say
Number of U.S. AIDS cases increase
Race plays role in new drug trials
Europe refuses to match US cash for ailing Global Fund
Critics rap CDC shift on funding HIV prevention
CDC announces new system for tracking HIV infections nationwide
New HIV test able to track when person was infected
Kenya: 12% of students infected with HIV
AIDS threat alarms Indian prime minister
India and AIDS — dodging the issue?
AIDS specialist wins first round in AZT patent fight
Kenya: final trials for AIDS vaccine planned, recruits needed
U.N. official calls India major AIDS hub
AIDS prevention groups fear U.S. funding cuts
Free HIV drugs in Brazil have boosted AIDS survival
U.S. House passes $17.1 billion in foreign aid with AIDS funds
Hispanics comprise growing number of U.S. AIDS cases
India announces 4.58 million Indians infected with HIV/AIDS
Smash sexual taboos, UN's AIDS tsar tells India
HIV patients have more heart disease risk factors
First-ever national parliamentary convention on HIV/AIDS in India
Top HIV experts convene at 2003 National HIV Prevention Conference
A fast-dimming bright spot on the AIDS map of Africa
U.S. House rejects bids to boost global AIDS funds
Pneumocystis still a problem in drug users with AIDS
Indian meeting sets up Asian anti-AIDS fight
AIDS and growth
Tainted AIDS drugs may be in Florida stores
HIV testing should not be used to restrict access to UK, report says
Pregnant Hong Kong women need HIV education
CCR5 inhibitor is effective HIV microbicide in monkeys
A desperate global scavenger hunt to keep AIDS patients alive
USAID launched presidential HIV prevention initiative in Haiti
Strong leadership and straight talking help Uganda to curb AIDS
New AIDS chief appointed at WHO
Act against AIDS (opinion)
Incoming UN health chief to make major announcement on HIV/AIDS
Tiny protein could be big piece of AIDS puzzle
Device gives women hope against AIDS
The needle swappers are still wary
Activists take helm in the global war against AIDS
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Latest Journal Headlines   [What is this?]
Vaccines:
In vivo kinetics and biodistribution of a HIV-1 DNA vaccine after administration in mice. Archives of Pharmacal Research.
Immunogenicity and protective efficacy of oral recombinant Lactococcus lactis expressing Env. Blood.
Specific nature of cellular immune responses elicited by chimpanzees against HIV-1. Human Immunology.
HLA-A*3303-restricted, HIV type 1 pol- and gag-derived cytotoxic T cell epitopes. AIDS Research and Human Retroviruses.
Studies on the generation and maintenance of mucosal CTL against HIV-1 gag in mice. AIDS Research and Human Retroviruses.
Progress toward the development of an HIV-1 bacterial vaccine vector. FEMS Immunology and Medical Microbiology.
Role of complement in the control of HIV dynamics and pathogenesis. Vaccine.
Innate and adaptive mucosal immunity in protection against HIV infection. Vaccine.
Prior DNA immunization enhances immune response to dominant and subdominant viral epitopes. Virology.
DNA vaccination of macaques by a full-genome SHIV plasmid chimera that produces non-infectious virus. Journal of General Virology.
Cross-reactive CD8+ T cell epitopes identified in US adolescent minorities. Journal of Acquired Immune Deficiency Syndromes.
Prevention:
Characteristics of individuals with male-to-male and heterosexually acquired infectious syphilis. Sexually Transmitted Diseases.
Sexual transmission of HIV in Africa. Nature.
Viral infections among HIV-infected and high-risk HIV-uninfected women. Journal of Infectious Diseases.
Advancing HIV prevention: New strategies for a changing epidemic — United States, 2003. Morbidity and Mortality Weekly Report.
Rapid fingerstick testing: A new era in HIV diagnostics. AIDS Clinical Care.
HIV incidence among street youth in Montreal, Canada. AIDS.
The contribution of steady and casual partnerships to the incidence of HIV infection. AIDS.
Public policy regulating private and public space in gay bathhouses. Journal of Acquired Immune Deficiency Syndromes.
Rectal use of nonoxynol-9 among men who have sex with men. AIDS.
Risk factors for incident HIV infection among anonymous HIV testing site clients. Journal of Acquired Immune Deficiency Syndromes.
Incubation and duration of specific symptoms at ARS as independent predictors of progression to AIDS. Journal of Acquired Immune Deficiency Syndromes.
Voluntary HIV testing among inmates. Journal of Acquired Immune Deficiency Syndromes.
Comparison of two strategies for administering nevirapine to prevent perinatal HIV transmission. Journal of Acquired Immune Deficiency Syndromes.
Intensive injection cocaine use as the primary risk factor in the Vancouver HIV-1 epidemic. AIDS.
Is breastfeeding best for HIV-positive mothers?. AIDS.
NeuroAIDS:
Chlamydophila pneumoniae and HIV-associated dementia complex. Journal of Neuroimmunology.
HIV-associated Guillain-Barre syndrome. Journal of the Neurologicals Sciences.
Virology:
B7-H1 is up-regulated in HIV infection and is a novel surrogate marker of disease progression. Blood.
HIV-1 Tat can favor the establishment of neoplasia. Journal of Biological Chemistry.
Inhibition of human immunodeficiency virus type 1 env-mediated fusion by DC-SIGN. Journal of Virology.
Increased in vitro cytopathicity of R5/NSI HIV-1 correlates with a progressive course of infection. Journal of Infectious Diseases.
Decreased stimulation of CD4+ T cell proliferation and IL-2 production by infected dendritic cells. Journal of Immunology.
Review: AIDS pathogenesis: what have two decades of HIV research taught us?. Nature Reviews Immunology.
Natural variation of the nef gene in human immunodeficiency virus type 2 infections in Portugal. Journal of General Virology.
Clade B HIV-1 superinfection with wild-type virus after primary infection. AIDS.
Serum immunoglobulin A (IgA)-mediated immunity in HIV-2 infection. Virology.
The functional relationship between V3 loop and gp120 context with regard to HIV coreceptor usage. Virology.
In-utero transmission of quasispecies among human immunodeficiency virus type 1 genotypes. Virology.
Transmission of HIV-1 infection between trophoblast placental cells and T-cells. Virology.
Heterogeneous clearance rates of long-lived lymphocytes infected with HIV. Proc. Natl. Acad. Sci. USA.
Innate immunity in HIV infection: Effect of viremia on natural killer cell function. Journal of Infectious Diseases.
Microanatomic relationships between CD8+ cells and HIV-1-producing cells in human lymphoid tissue. Journal of Acquired Immune Deficiency Syndromes.
Bystander CD4(+) T lymphocytes survive in HIV-infected human lymphoid tissue. AIDS Research and Human Retroviruses.
Enhanced transcytosis of R5 HIV across tight monolayer of polarized human endometrial cells. Cytokine.
A more accurate assessment of HIV-1 replication dynamics and T-cell decay in vivo. Journal of Virology.
Latent viral reservoir in a SIV-Macaca nemestrina model of HIV-1-infected patients on HAART. Journal of Virology.

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