Antibody domain exchange is an immunological solution to carbohydrate cluster recognition
The structures of Fab of human antibody 2G12 alone and bound to either an oligosaccharide or a disaccharide show that the Fabs form an unusual domain-swapped dimer with an extended surface that allows high-affinity recognition of the carbohydrate epitope on gp120.
By Daniel A. Calarese et al.
Media commentary: HIV find could help vaccine makers
The need for a global HIV vaccine enterprise
A new collaborative model of research is needed to increase resources, to prioritize the R&D agenda of the major public and private sector stakeholders, and ultimately to increase the probability and shorten the time to development of effective HIV vaccines for global use.
By Richard D. Klausner et al.
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Exposed uninfected individuals: CD4 cell and CD8 cell-mediated resistance to HIV-1 infection
Relative resistance to PBMC infection with HIV-1 in 21 out of 45 exposed uninfected IDU, but only in 5 out of 50 unexposed controls. PBMC resistance was related either to an inhibition of HIV-1 replication in CD4 cells or to CD8 cell-mediated viral suppression. AIDS 17(10), 1425, 2003.
Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells
Even in HAART treated patients who have had no detectable viremia for as long as 7 years, the HIV-1 reservoir in resting CD4+ T cells decays so slowly (t1/2 = 44 months) that eradication is unlikely. Nature Medicine 9(6), 727, June 2003.
Many gay, bisexual men report unsafe sex
Among 4295 men, 48.0% and 54.9%, respectively, reported unprotected receptive and insertive anal sex in the previous 6 months. Unprotected sex was significantly more likely with 1 primary partner or multiple partners than with 1 nonprimary partner. American Journal of Public Health 93(6), 926, June 2003.
Sex without disclosure of positive HIV serostatus
The authors estimated the proportion of HIV-positive adults who have any sexual contact without disclosure and the proportion of their sexual partnerships that involve unprotected sex without disclosure. The results of this study indicate that sex without disclosure of HIV status is relatively common among persons living with HIV. American Journal of Public Health 93(6), 949, June 2003.
Late versus early testing of HIV 16 sites, United States, 2000-2003
To characterize HIV-testing patterns among HIV-infected persons, the U.S. CDC analyzed data from a multisite interview project. Reducing the incidence of both new infections and HIV-associated morbidity and mortality will require earlier testing and improved access to prevention and care services for persons infected with HIV. Morbidity and Mortality Weekly Report 52(25), 581, June 27, 2003