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February 6, 2016
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Vol. 3, No. 9, 16 May 2003
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From Science:
AIDS RESEARCH: Drug trials without the drugs?
The U.S. National Institute of Allergy and Infectious Diseases (NIAID), wants to encourage research on the best ways to deliver AIDS therapies in developing countries, but it is concerned that the cost of buying drugs for such studies would swamp its research budget.

— By Jon Cohen 
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Hot News:
Some exposed seronegative individuals may be infected
New evidence for HIV-1 infection in two exposed seronegative (ES) individuals below the detection limit of standard assays, suggests that extraordinary control of infection can occur. Journal of Virology 77(11), 6108, June 2003.
Augmentation of HIV-1-specific T helper cell responses in chronic HIV-1 infection by therapeutic immunization
The augmentation of HIV-1-specific T helper cell responses was achieved in five out of five vaccine recipients and none out of four controls by therapeutic immunization in individuals with chronic infection on suppressive ART. AIDS 17(8), 1121, 2003.
Comparative immunogenicity in monkeys of DNA, recombinant vaccinia virus, and replication-defective adenovirus vectors expressing Gag
Adenovirus type 5-mediated gene transfer provided an extremely potent means of inducing anti-HIV-1 T-cell responses, specifically CTL. Preexisting immunity directed at the viral vector itself only reduced, but did not abolish anti-Gag T-cell responses. Journal of Virology 77(11), 6305, June 2003.
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Latest Journal Headlines   [What is this?]
Vpr R77Q is associated with long-term nonprogressionve infection and impaired induction of apoptosis. Journal of Clinical Investigation.
Cellular immune responses to helper-free HSV-1 amplicons encoding gp120 are enhanced by DNA priming. Vaccine.
Enhanced cellular immune responses to SIV Gag by immunization with flu and vaccinia recombinants. Vaccine.
Combined use of recombinant fowlpox viruses, plasmids and virus-like particles in prime-boost. Vaccine.
Estimation of "needs" and "probable uptake" for HIV/AIDS preventive vaccines. Vaccine.
The induction of HIV Gag-specific CD8+ T cells in the spleen and GALT. Journal of Immunology.
Definition of two new epitopes on HIV-1 gag protein recognized by human CD8+ CTL clones. Journal of Clinical Virology.
Identification of immunodominant epitopes in inactivated Tat-vaccinated volunteers. Journal of Acquired Immune Deficiency Syndromes.
Infection of macaques with a subtype B R5-tropic SHIV bearing a subtype E V3 loop. Archives of Virology.
HIV-gp160 modulates differentially the production in vitro of IgG, IgA and cytokines. Clinical and Experimental Immunology.
Characteristics of individuals with male-to-male and heterosexually acquired infectious syphilis. Sexually Transmitted Diseases.
Sexual transmission of HIV in Africa. Nature.
Viral infections among HIV-infected and high-risk HIV-uninfected women. Journal of Infectious Diseases.
Advancing HIV prevention: New strategies for a changing epidemic — United States, 2003. Morbidity and Mortality Weekly Report.
Rapid fingerstick testing: A new era in HIV diagnostics. AIDS Clinical Care.
HIV incidence among street youth in Montreal, Canada. AIDS.
The contribution of steady and casual partnerships to the incidence of HIV infection. AIDS.
Public policy regulating private and public space in gay bathhouses. Journal of Acquired Immune Deficiency Syndromes.
Rectal use of nonoxynol-9 among men who have sex with men. AIDS.
Risk factors for incident HIV infection among anonymous HIV testing site clients. Journal of Acquired Immune Deficiency Syndromes.
Incubation and duration of specific symptoms at ARS as independent predictors of progression to AIDS. Journal of Acquired Immune Deficiency Syndromes.
Voluntary HIV testing among inmates. Journal of Acquired Immune Deficiency Syndromes.
Comparison of two strategies for administering nevirapine to prevent perinatal HIV transmission. Journal of Acquired Immune Deficiency Syndromes.
Intensive injection cocaine use as the primary risk factor in the Vancouver HIV-1 epidemic. AIDS.
Is breastfeeding best for HIV-positive mothers?. AIDS.
Chlamydophila pneumoniae and HIV-associated dementia complex. Journal of Neuroimmunology.
HIV-associated Guillain-Barre syndrome. Journal of the Neurologicals Sciences.
B7-H1 is up-regulated in HIV infection and is a novel surrogate marker of disease progression. Blood.
HIV-1 Tat can favor the establishment of neoplasia. Journal of Biological Chemistry.
Inhibition of human immunodeficiency virus type 1 env-mediated fusion by DC-SIGN. Journal of Virology.
Increased in vitro cytopathicity of R5/NSI HIV-1 correlates with a progressive course of infection. Journal of Infectious Diseases.
Decreased stimulation of CD4+ T cell proliferation and IL-2 production by infected dendritic cells. Journal of Immunology.
Review: AIDS pathogenesis: what have two decades of HIV research taught us?. Nature Reviews Immunology.
Natural variation of the nef gene in human immunodeficiency virus type 2 infections in Portugal. Journal of General Virology.
Clade B HIV-1 superinfection with wild-type virus after primary infection. AIDS.
Serum immunoglobulin A (IgA)-mediated immunity in HIV-2 infection. Virology.
The functional relationship between V3 loop and gp120 context with regard to HIV coreceptor usage. Virology.
In-utero transmission of quasispecies among human immunodeficiency virus type 1 genotypes. Virology.
Transmission of HIV-1 infection between trophoblast placental cells and T-cells. Virology.
Heterogeneous clearance rates of long-lived lymphocytes infected with HIV. Proc. Natl. Acad. Sci. USA.
Innate immunity in HIV infection: Effect of viremia on natural killer cell function. Journal of Infectious Diseases.
Microanatomic relationships between CD8+ cells and HIV-1-producing cells in human lymphoid tissue. Journal of Acquired Immune Deficiency Syndromes.
Bystander CD4(+) T lymphocytes survive in HIV-infected human lymphoid tissue. AIDS Research and Human Retroviruses.
Enhanced transcytosis of R5 HIV across tight monolayer of polarized human endometrial cells. Cytokine.
A more accurate assessment of HIV-1 replication dynamics and T-cell decay in vivo. Journal of Virology.
Latent viral reservoir in a SIV-Macaca nemestrina model of HIV-1-infected patients on HAART. Journal of Virology.

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