IMMUNOLOGY: Requirement for CD4 T cell help in generating functional CD8 T cell memory
A previously undescribed role for CD4 cell help in the development of functional CD8 memory.
By Devon J. Shedlock and Hao Shen
IMMUNOLOGY: CD8 T cells remember with a little help
During their differentiation, memory CD8 T cells need help from CD4 T cells to ensure formation of a recall response that is robust in both quality and quantity.
By Susan M. Kaech and Rafi Ahmed
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Advancing HIV prevention: New strategies for a changing epidemic United States, 2003
In response to recent outbreaks of syphilis among MSM, and increases in newly diagnosed HIV infections among MSM and among heterosexuals, the U.S. CDC, in partnership with other agencies will launch a new prevention initiative.
From Medscape: Oral sex among MSM and risk of HIV
Researchers acknowledged that fellatio, although not an efficient route of infection, nonetheless appeared to carry a small risk. AIDS Reader 13(1), 10, 2003 (Medscape requires a one-time registration).
See also, AIDS 16(17), 2350, 2002.
Immunogenicity of a recombinant HIV canarypox vaccine in Uganda
Immunogenicity was low in this first preventative clade B-based HIV vaccine study in Africa, but it elicited CD8+ T cell responses with detectable cross-activity against clade A and D antigens in a significant proportion of vaccine recipients. Journal of Infectious Diseases 187, 887, 15 March 2003.
IAVI gives details on Merck and Aventis partnering to test an AIDS vaccine
Merck & Co Inc. and Aventis Pasteur announced that they are partnering to conduct human trials of a new vaccine to prevent HIV/AIDS, which has two components: one named MRKAd5 and built by Merck, and a second named ALVAC by Aventis.
HIV in central and eastern Europe
During the past 5 years, most countries of the former Soviet Union have been severely affected by HIV epidemics that continue to spread as a result of injecting drug use. Eastern Europe will soon be confronted with a major AIDS epidemic. Lancet, 361, 1035, 22 March, 2003.
Neutralizing antibody response and virus escape
Two papers examine how antibodies quickly eliminate neutralization-sensitive HIV in early infection, only to be replaced by populations of resistant virus. One of the teams discovered that the glycan moieties of env change — rather than protein epitopes — in yet another mechanism of viral escape. Nature 422, 307, 20 March 2003.
See also, Proc. Natl. Acad. Sci. USA, published online 18 March, 2003.